Research Activity

Scientific design and realization of new methodologies related to the preservation of Decellularized Dermis: the freeze-drying
The project is aimed to realize new methods for the storage of Decellularized dermis produced at Skin Bank ERR. In particular, the project aims to develop a method for the freeze-drying of the Decellularized dermis, able to maintain the structural characteristics of tissue and its storage at room temperature under sterile conditions.

Scientific design and realization of a new method for the decellularization of rotator cuff and its clinical applications in the field of Regenerative Medicine
The project aims to develop a new method for the decellularization of the rotator cuff of the shoulder derived from human donors, in order to obtain a cell-free scaffold with the same anatomical-structural characteristics of the injured tissue. In a second step, we will proceed to the certification of suitability use in the orthopedic field according to current regulations.

Publications

Rotini R., Marinelli A., Guerra E., BettelliG., Castagna A., Fini M., Bondioli E., Busacca M. (2011)
“Human dermal matrix scaffold augmentation for large and massive rotator cuff repairs: preliminary clinical and MRI results at 1-year follow-up”
Musculoskelet Surg 95(Suppl 1):S13-S23; doi 10.1007/s12306-011-0141-8.

Fini M., Bondioli E., Castagna A., Torricelli P., Giavaresi G., Rotini R., Marinelli A., Guerra E., Orlandi C., Carboni A., Aiti A., Benedettini E., Giardino R. and Melandri D. (2012)
“Decellularized Human Dermis to Treat Massive Rotator Cuff Tears: In Vitro Evaluations”
Connective Tissue Research 53(4): 298–306; doi: 10.3109/03008207.2011.649929.

Giavaresi G., Bondioli E., Melandri D., Giardino R., Tschon M., Torricelli P., Cenacchi G., Rotini R., Castagna A., Veronesi F., Pagani S. and Fini M. (2013)
“Response of human chondrocytes and mesenchymal stromal cells to a decellularized human dermis”
BMC Musculoskeletal Disorders 14:12.